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The time now is Add Thread to del. Successfully unlocked an iPhone 4s on 7. User Name. Remember Me? Root any Device. The efficiency of this molecular test suggests that Sardinians may represent a suitable population for a preconceptional screening. Five hundred couples of Sardinia descent were screened for 38 mutations using a semi-automated reverse-dot blot and PCR-gel electrophoresis assays.

This mutation panel included the 15 most frequent CF alleles in Sardinia. The most common CF allele was the p. Phedel Fdel We also identified one couple at risk and an asymptomatic female homozygote for the p. ThrIle allele. Published by Elsevier B. All rights reserved. Carrier screening for cystic fibrosis. Cystic fibrosis is the first genetic disorder for which universal screening of preconceptional or prenatal patients became a component of standard prenatal care.

The molecular genetics and mutation profile of the CFTR gene are complex, with a wide range of phenotypic consequences. Carrier screening can facilitate risk assessment for prospective parents to have an affected offspring, although there remains a small residual risk for carrying a mutation even with a negative screening result. There are ethnic differences with respect to disease incidence and effectiveness of carrier testing, which may complicate counseling. Copyright c Elsevier Inc. What Is Carrier Screening?

Testing What Is Genetic Counseling? Responsible implementation of expanded carrier screening. This document of the European Society of Human Genetics contains recommendations regarding responsible implementation of expanded carrier screening.

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Carrier screening is defined here as the detection of carrier status of recessive diseases in couples or persons who do not have an a priori increased risk of being a carrier based on their or their partners' personal or family history. Expanded carrier screening offers carrier screening for multiple autosomal and X-linked recessive disorders, facilitated by new genetic testing technologies, and allows testing of individuals regardless of ancestry or geographic origin.

Carrier screening aims to identify couples who have an increased risk of having an affected child in order to facilitate informed reproductive decision making. In previous decades, carrier screening was typically performed for one or few relatively common recessive disorders associated with significant morbidity, reduced life-expectancy and often because of a considerable higher carrier frequency in a specific population for certain diseases.

New genetic testing technologies enable the expansion of screening to multiple conditions, genes or sequence variants. Expanded carrier screening panels that have been introduced to date have been advertised and offered to health care professionals and the public on a commercial basis. This document discusses the challenges that expanded carrier screening might pose in the context of the lessons learnt from decades of population-based carrier screening and in the context of existing screening criteria.

It aims to contribute to the public and professional discussion and to arrive at better clinical and laboratory practice guidelines. Carrier screening for single gene disorders. Screening for genetic disorders began in with the initiation of newborn screening for phenylketonuria. Advances in molecular technology have made both newborn screening for newborns affected with serious disorders, and carrier screening of individuals at risk for offspring with genetic disorders, more complex and more widely available.

Carrier screening today can be performed secondary to family history-based screening , ethnic-based screening , and expanded carrier screening ECS.

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ECS is panel-based screening , which analyzes carrier status for hundreds of genetic disorders irrespective of patient race or ethnicity. In this article, we review the historical and current aspects of carrier screening for single gene disorders, including future research directions. Carrier Screening: Past, Present, and Future. To date, preconceptual and prenatal patients have been offered gene-by-gene, disorder-by-disorder carrier screening. Newer techniques allow screening of many disorders at one time. Expanded carrier screening ECS is a relatively new carrier screening option that assesses many conditions simultaneously, as opposed to traditional ethnicity-based carrier screening for a limited number of conditions.

This study aimed to explore pregnant women's perspectives on ECS, including reasons for electing or declining and anxiety associated with this decision-making. A total of 80 pregnant women were surveyed from Northwestern Medicine's Clinical Genetics Division after presenting for aneuploidy screening.

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Of the 80 participants, 40 elected and 40 declined ECS. Trends regarding reasons for electing or declining ECS include ethnicity, desire for genetic risk information, lack of family history, perceived likelihood of being a carrier , and perceived impact on reproductive decisions. Individuals who declined ECS seemed to prefer ethnicity-based carrier screening and believed that ECS would increase their anxiety, whereas individuals who elected ECS seemed to prefer more screening and tended to believe that ECS would reduce their anxiety.

These findings provide insight on decision-making with regard to ECS and can help guide interactions that genetic counselors and other healthcare providers have with patients, including assisting patients in the decision-making process. The impact of a national population carrier screening program on cystic fibrosis birth rate and age at diagnosis: Implications for newborn screening. Population carrier screening PCS has been available in Israel since and universally subsidized since We sought to evaluate its impact.

A retrospective review of governmental databanks, the national CF registry and CF centers. CF rate per , live births has decreased from From there were 95 CF births: PCS markedly reduced CF birth rates with a shift towards milder mutations, but was often avoided for cultural reasons. As children regularly have significant disease at diagnosis, we suggest a balanced approach, utilizing both PCS and newborn screening.

Cystic fibrosis carrier screening in Veneto Italy: A recent study by Castellani et al. JAMA We discuss some of the ethical issues raised by the policies and individual choices that are the subject of this study.

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Some Considerations for Governments. Consideration of expanded carrier screening has become an emerging issue for governments. However, traditional criteria for decision-making regarding screening programs do not incorporate all the issues relevant to expanded carrier screening. Further, there is a lack of consistent guidance in the literature regarding the development of appropriate criteria for government assessment of expanded carrier screening.

Given this, a workshop was held to identify key public policy issues related to preconception expanded carrier screening , which governments should consider when deciding whether to publicly fund such programs.

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It was structured around two design features: Forty-one international experts attended the workshop. The deliberations centered primarily on the conditions to be tested and the elements of the screening program itself. Participants expected only severe conditions to be screened but were concerned about the lack of a consensus definition of "severe. Participants also made arguments for consideration of the accuracy of screening tests.

A wide range of issues require careful consideration by governments that want to assess expanded carrier screening. Traditional criteria for government decision-making regarding screening programs are not a "best fit" for expanded carrier screening and new models of decision-making with appropriate criteria are required.


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There is a need to define what a "severe" condition is, to build. Psychological screening program overview. This article reviews the literature on health surveillance conducted during military deployments, focusing on models for assessing the impact of operational deployments on peacekeepers. A discussion of the stressors and potential mental health consequences of peacekeeping operations follows with relevant examples of findings from U.

Psychological screening in different peacekeeping operations conducted in U. Army-Europe is reviewed. The review begins with the redeployment screening of military personnel deployed to Bosnia mandated under the Joint Medical Surveillance Program , and continues through the present screening of units deployed to Kosovo. The detailed description of the screening program includes a discussion of procedures and measures and demonstrates the evolution of the program. A summary of key findings from the screening program and a discussion of future research directions are provided. Carrier screening in the era of expanding genetic technology.

The Center for Jewish Genetics provides genetic education and carrier screening to individuals of Jewish descent. Carrier screening has traditionally been performed by targeted mutation analysis for founder mutations with an enzyme assay for Tay-Sachs carrier detection. The development of next-generation sequencing NGS allows for higher detection rates regardless of ethnicity.

Here, we explore differences in carrier detection rates between genotyping and NGS in a primarily Jewish population. Peripheral blood samples or saliva samples were obtained from individuals. All samples were analyzed by sequencing, targeted genotyping, triplet-repeat detection, and copy-number analysis; the analyses were carried out at Counsyl. Of individuals screened , were identified as carriers of at least 1 condition and 8 couples were carriers for the same disorder. A total of pathogenic variants were identified. Three hundred twelve variants would have been detected via genotyping alone.

Although no additional mutations were detected by NGS in diseases routinely screened for in the Ashkenazi Jewish population, In a primarily Jewish population, NGS reveals a larger number of pathogenic variants and provides individuals with valuable information for family planning. Genet Med 18 12, Thalassaemia screening and confirmation of carriers in parents.

Haemoglobinopathies are among the most common inherited monogenic disorders worldwide. Thalassaemia screening for carrier status is recommended for adults of reproductive age if suspected of being at risk. Conventional laboratory methods for screening include the assessment of haematological indices, and high-performance liquid chromatography, capillary electrophoresis or isoelectric focusing to measure the levels of HbA 2 and HbF, and to identify haemoglobin variants.

Each screening method has its advantages and disadvantages, the main disadvantage being that none can fully resolve all variants. The complex nature of the genetics of haemoglobinopathies necessitates expertise in the interpretation of screening results to evaluate the most likely genotypes, which must then be confirmed using the DNA diagnosis.

This review highlights the limits and pitfalls of each screening technique, and outlines a rational combination of different methods to overcome issues in thalassaemia carrier detection. Published by Elsevier Ltd. The offering and acceptance of expanded carrier screening is increasing among pregnant women including women without an increased risk based on race, ethnicity or family history.

Yet, little is known about the way these tests are offered and how patients are affected by a positive test result. A content analysis was conducted on the transcript data from the interviews. Outcomes of this research suggest that educational interventions are needed to improve maternal understanding of positive carrier screening results. Most of the participants in this study confused the results with other prenatal screening test options.

In addition, the way the results were discussed varied greatly, and influenced participants' thoughts about reproductive decisions that led to a range of emotional uncertainty. Our data suggests that genetic counseling improved participants' understanding of positive results. More research is needed to further understand if our results are consistent within a larger, more diverse sample, and to explore how to best provide education about expanded carrier screening. Cystic fibrosis carrier screening in a North American population. The aim of this study was to compare the mutation frequency distribution for a mutation panel and a mutation panel used for cystic fibrosis carrier screening.

Further aims of the study were to examine the race-specific detection rates provided by both panels and to assess the performance of extended panels in large-scale, population-based cystic fibrosis carrier screening. Expanded panels using race-specific variants can improve cystic fibrosis carrier detection rates within specific populations.

However, it is important that the pathogenicity and the relative frequency of these variants are confirmed. Ethnicity-based carrier screening for the Ashkenazi Jewish population has been available and encouraged by advocacy and community groups since the early 's. Both the American College of Medical Genetics and the American Congress of Obstetricians and Gynecologists recommend carrier screening for this population Obstetrics and Gynecology, 4 , , ; Genetics in Medicine, 10 1 , , While many physicians inquire about ethnic background and offer appropriate carrier screening , studies show that a gap remains in implementing recommendations Genetic testing and molecular biomarkers, In addition, education and outreach efforts targeting Jewish communities have had limited success in reaching this at-risk population.

Despite efforts by the medical and Jewish communities, many Jews of reproductive age are not aware of screening , and remain at risk for having children with preventable diseases. Reaching this population, preferably pre-conception, and facilitating access to screening is critically important. To address this need, genetic counselors at Emory University developed JScreen, a national Jewish genetic disease screening program. The program includes a national marketing and PR campaign, online education, at-home saliva-based screening , post-test genetic counseling via telephone or secure video conferencing, and referrals for face-to-face genetic counseling as needed.

Our goals are to create a successful education and screening program for this population and to develop a model that could potentially be used for other at-risk populations. Screening of gestational carriers in the United States. Objective To assess medical and psychosocial screening and evaluation received by gestational carriers and compare those using agencies to those not using agencies.

Design Cross-sectional questionnaire. Setting Online. Patients women who completed a survey on their experiences as gestational carriers in the United States. Intervention s None. Main Outcome Measure s Self-reported screening received prior to gestational carrier pregnancies. Results Overall, Most participants indicated that they had been informed of at least some medical risks Participants most often recalled being informed of the risks of multiple pregnancy There were no differences between those who used an agency and those who did not on any outcome measures.

Further education of providers regarding guidelines for the screening and evaluation of gestational carriers may be needed. Understanding sickle cell carrier status identified through newborn screening: The expansion of newborn screening NBS is increasing the generation of incidental results, notably carrier results. Although carrier status is generally understood to be clinically benign, concerns persist that parents may misunderstand its meaning, with deleterious effects on children and their families. Expansion of the NBS panel in Ontario, Canada in to include sickle cell disorders drew attention to the policy challenge of incidental carrier results.

We conducted a study of consumer and provider attitudes to inform policy on disclosure. In this paper, we report the results of i qualitative interviews with health-care providers, advocates and parents of carrier infants and ii focus groups with new parents and individuals active with the sickle cell community. Lay and provider participants generally believed that carrier results were clinically insignificant.

However, some uncertainty persisted among lay consumers in the form of conjecture or doubt. In addition, consumers and advocates who were most informed about the disease articulated insistent yet dissonant claims of clinical significance. Meanwhile, providers referenced research knowledge to offer an equivocal assessment of the possibility and significance of clinically symptomatic carrier status. Disclosure policy related to incidentally generated infant carrier results needs to account for these complex realities. Screening in crystalline liquids protects energetic carriers in hybrid perovskites.

Hybrid lead halide perovskites exhibit carrier properties that resemble those of pristine nonpolar semiconductors despite static and dynamic disorder, but how carriers are protected from efficient scattering with charged defects and optical phonons is unknown. Here, we reveal the carrier protection mechanism by comparing three single-crystal lead bromide perovskites: The hot fluorescence is correlated with liquid-like molecular reorientational motions, suggesting that dynamic screening protects energetic carriers via solvation or large polaron formation on time scales competitive with that of ultrafast cooling.

Similar protections likely exist for band-edge carriers. The long-lived energetic carriers may enable hot- carrier solar cells with efficiencies exceeding the Shockley-Queisser limit. This work was supported by U. Preconception carrier screening for multiple disorders: Technological developments have enabled carrier screening for multiple disorders. This study evaluated experiences with a preconception carrier screening offer for four recessive disorders in a Dutch founder population.

Questionnaires were completed by attendees pretesting and posttesting and by non-attendees. Semistructured interviews were conducted with seven of the eight carrier couples. Familiarity with the genetic disorders was high. All carrier couples made reproductive decisions based on their results. Main reason for non-attendance was unawareness of the screening offer. With expanded carrier screening , adequately informing couples pretest and posttesting is of foremost importance.

Our findings provide lessons for the implementation of expanded carrier screening panels in other communities and other settings. Microfluidics-assisted in vitro drug screening and carrier production. Microfluidic platforms provide several unique advantages for drug development. In the production of drug carriers , physical properties such as size and shape, and chemical properties such as drug composition and pharmacokinetic parameters, can be modified simply and effectively by tuning the flow rate and geometries.

Large numbers of carriers can then be fabricated with minimal effort and with little to no batch-to-batch variation. Additionally, cell or tissue culture models in microfluidic systems can be used as in vitro drug screening tools. Compared to in vivo animal models, microfluidic drug screening platforms allow for high-throughput and reproducible screening at a significantly lower cost, and when combined with current advances in tissue engineering, are also capable of mimicking native tissues.

In this review, various microfluidic platforms for drug and gene carrier fabrication are reviewed to provide guidelines for designing appropriate carriers. In vitro microfluidic drug screening platforms designed for high-throughput analysis and replication of in vivo conditions are also reviewed to highlight future directions for drug research and development. The identification in of the cystic fibrosis CF gene and its most common mutation immediately raised the possibility of CF carrier detection by DNA analysis.

It was also stated that screening of individuals or couples in the general population should not be offered until the rate of CF carrier detection improves. An additional prerequisite emphasized the need for the establishment of effective educational and counseling programs consistent with previous widely accepted principles. ASHG recommendations are that screening be limited to individuals with a family history of CF, testing should be accompanied by education and counseling, screening should be voluntary and confidential with appropriate laboratory quality controls, and efforts should be expanded to educate health care providers and the public.

Genomics-based carrier screening is one of many opportunities to use genomic information to inform medical decision making, but clinicians, health care delivery systems, and payers need to determine whether to offer screening and how to do so in an efficient, ethical way. To shed light on this issue, we conducted a study in the period to inform the design of clinical screening programs and guide further health services research. Many of our results have been published elsewhere; this article summarizes the lessons we learned from that study and offers policy insights.

Our experience can inform understanding of the potential impact of expanded carrier screening services on health system workflows and workforces-impacts that depend on the details of the screening approach. We found limited patient or health system harms from expanded screening. We also found that some patients valued the information they learned from the process. Future policy discussions should consider the value of offering such expanded carrier screening in health delivery systems with limited resources.

Carrier screening for hemoglobinopathies HbPs; sickle cell disease and thalassemia aims to facilitate autonomous reproductive decision-making. In the absence of a Dutch national HbP carrier screening program , some primary care midwives offer screening on an ad hoc basis. This qualitative descriptive study explores how pregnant women perceive an offer of HbP carrier screening by their midwife. The results showed that half of the respondents were familiar with HbPs.

Seven declined, of whom two already knew their carrier status. Important reasons to accept screening were to obtain knowledge about their own carrier status and health of their unborn child, and the ease of the procedure. A multistep process of decision-making was observed, as many women did not give follow-up testing e. Women experienced information overload, and preferred receiving the information at a different moment e. In conclusion, while prenatal HbP carrier screening is perceived as positive, informed decision-making seems to be suboptimal, and both the content and timing of the information provided needs improvement.

Preconception Carrier Screening by Genome Sequencing: Results from the Clinical Laboratory. Advances in sequencing technologies permit the analysis of a larger selection of genes for preconception carrier screening. We report here on the clinical laboratory results from this expanded carrier screening program. Variants were filtered and classified using the latest American College of Medical Genetics and Genomics ACMG guideline; only pathogenic and likely pathogenic variants were confirmed by orthologous methods before being reported.

Novel missense variants were classified as variants of uncertain significance. We reported variants in participants. For novel splice-site variants, RNA-splicing assays were performed to aid in classification. We reported ten copy-number variants and five variants in non-coding regions. One novel variant was reported in F8, associated with hemophilia A; prenatal testing showed that the male fetus harbored this variant and the neonate suffered a life-threatening hemorrhage which was anticipated and appropriately managed.

Compared with targeted mutation screening , genome sequencing improves the sensitivity of detecting clinically significant variants. While certain novel variant interpretation remains challenging, the ACMG guidelines are useful to classify variants in a healthy population.

Published by Elsevier Inc. Federal Register , , , , Cystic fibrosis: Involving a Citizens' jury in decisions on screening carrier. In recent years, the continuous improvements in molecular biology techniques have made it possible to detect carriers for several genetic conditions, including cystic fibrosis CF. In some countries, CF carrier screening is offered to increasing subset of the general population.

Offering of carrier screening at a population level should not be decided by local health authorities only, without consulting citizens' preferences. One way to involve citizens in the decision process might be to a Citizens' jury, a method of deliberative democracy. The object of the study is to produce a recommendation statement about CF carrier screening using a Citizens' jury. As this is a new method in the field, the study also provided the opportunity to evaluate its effectiveness.

The project is designed and managed by an executive committee. The whole process is superintended by a multidisciplinary scientific committee. The 16 members of the jury attend a 1 day meeting, assisted by a non-medical and unbiased facilitator. Informative material was prepared and distributed 15 days before the jury meeting; during the meeting, experts and witnesses interact directly with all the jurors through questions and answers.

All except one member of the jury felt positively about the Health Service actively providing population carrier screening for CF. The final statement was available to public, clinicians, researchers and decision-makers. In general, a Citizens' jury is a feasible method for involving citizens in public health decision-making process and in particular for obtaining a community view about CF carrier screening. Enhanced optical security by using information carrier digital screening. Jura has developed different security features based on Information Carrier Digital Screening. Substance of such features is that a non-visible secondary image is encoded in a visible primary image.

The encoded image will be visible only by using a decoding device. One of such developments is JURA's Invisible Personal Information IPI is widely used in high security documents, where personal data of the document holder are encoded in the screen of the document holder's photography and they can be decoded by using an optical decoding device.

In order to make document verification fully automated, enhance security and eliminate human factors, digital version of IPI, the D-IPI was developed. A special 2D-barcode structure was designed, which contains sufficient quantity of encoded digital information and can be embedded into the photo. Other part of Digital-IPI is the reading software, that is able to retrieve the encoded information with high reliability.

The reading software developed with a specific 2D structure is providing the possibility of a forensic analysis. Such analysis will discover all kind of manipulations -- globally, if the photography was simply changed and selectively, if only part of the photography was manipulated. Digital IPI is a good example how benefits of digital technology can be exploited by using optical security and how technology for optical security can be converted into digital technology.

Maryland motor carrier program performance enhancement: This includes roadside inspections: Maryland motor carrier program performance enhancement. Using the inspection summary data reports from SHA for years to and inspection and violation: MSP and Maryland Transporta The success of prenatal carrier screening as a disease prevention strategy in the Ashkenazi Jewish AJ population has driven the expansion of screening panels as disease-causing founder mutations have been identified. However, the carrier frequencies of many of these mutations have not been reported in large AJ cohorts.

We determined the carrier frequencies of over mutations for 16 recessive disorders in the New York metropolitan area AJ population. The carrier frequencies ranged from 0. Carrier screening also identified rare individuals homozygous for disease-causing mutations who had previously unrecognized clinical manifestations. Together, these data indicate the general acceptance, carrier frequencies, and prenatal testing results for an expanded panel of 16 diseases in the AJ population. Planning and Implementing Health Screening Programs. School health screening programs , which include screening , education of children and parents, and follow-up in the form of appropriate treatment, are described.

A scoliosis screening program is described as an example of the model presented. Suggestions for planners, participants, and evaluators of any school health screening are summarized. The safety impacts are examined by comparing the crash rates and driver Effectiveness of screening hospital admissions to detect asymptomatic carriers of Clostridium difficile: Both asymptomatic and symptomatic Clostridium difficile carriers contribute to new colonizations and infections within a hospital, but current control strategies focus only on preventing transmission from symptomatic carriers.

Our objective was to evaluate the potential effectiveness of methods targeting asymptomatic carriers to control C. We developed an agent-based transmission model for C. We simulated scenarios that vary according to screening test characteristics, colonization prevalence, and type of strain present at admission. Within the hospital-onset HO cases, approximately half were patients admitted as asymptomatic carriers who became symptomatic in the ward. Test sensitivity, turnaround time, colonization prevalence at admission, and strain type had significant effects on testing efficacy.

Testing for asymptomatic carriers at admission may reduce both the number of new colonizations and HO-CDI cases. Additional reductions could be achieved by preventing disease in patients who are admitted as asymptomatic carriers and developed CDI during the hospital stay. Results of a Disease Simulation Model. Our goal was to compare the effectiveness of different PAC screening strategies in BRCA2 mutation carriers , from the standpoint of life expectancy.

A previously published Markov model of PAC was updated and extended to incorporate key aspects of BRCA2 mutation carrier status, including competing risks of breast- and ovarian-cancer specific mortality. BRCA2 mutation carriers were modeled and analyzed as the primary cohort for the analysis. For each cohort, one-time screening and annual screening were evaluated, with screening starting at age 50 in both strategies.

The primary outcome was net gain in life expectancy LE compared to no screening. Sensitivity analysis was performed on key model parameters, including surgical mortality and MRI test performance. One-time screening at age 50 resulted in a LE gain of 3. Annual screening resulted in LE loss of Among BRCA2 mutation carriers , aggressive screening regimens may be ineffective unless additional indicators of elevated risk e.

More clinical studies are needed to confirm these findings. Respiratory physicians and clinic coordinators' attitudes to population-based cystic fibrosis carrier screening. Attitudes of Australian CF healthcare professionals toward population-based cystic fibrosis CF carrier screening were examined. A purpose-designed questionnaire was distributed to respiratory physicians and 30 CF clinic coordinators throughout Australia. Seventy-one questionnaires 52 physicians and 19 coordinators After the carrier has been identified, you may want to unlock your iPhone.

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